Systemic Antibiotic Therapy Reduces Circulating Inflammatory Dendritic Cells and Treg-Th17 Plasticity In Periodontitis

Authors

Language

English

Publication Date

5-1-2019

Journal

Journal of Immunology

DOI

10.4049/jimmunol.1900046

PMID

30944162

PMCID

PMC6857811

PubMedCentral® Posted Date

May 2019

PubMedCentral® Full Text Version

Post-print

Abstract

Periodontitis (PD) is a common dysbiotic inflammatory disease that leads to local bone deterioration and tooth loss. PD patients experience low-grade bacteremias with oral microbes implicated in the risk of heart disease, cancer, and kidney failure. Although Th17 effectors are vital to fighting infection, functional imbalance of Th17 effectors and regulatory T cells (Tregs) promote inflammatory diseases. In this study, we investigated, in a small pilot randomized clinical trial, whether expansion of inflammatory blood myeloid dendritic cells (DCs) and conversion of Tregs to Th17 cells could be modulated with antibiotics (AB) as part of initial therapy in PD patients. PD patients were randomly assigned to either 7 d of peroral metronidazole/amoxicillin AB treatment or no AB, along with standard care debridement and chlorhexidine mouthwash. 16s ribosomal RNA analysis of keystone pathogen

Keywords

Amoxicillin, Bacteria, Bacterial Infections, Dendritic Cells, Female, Humans, Male, Metronidazole, Middle Aged, Periodontitis, T-Lymphocytes, Regulatory, Th17 Cells

Recommended Citation

, "Systemic Antibiotic Therapy Reduces Circulating Inflammatory Dendritic Cells and Treg-Th17 Plasticity In Periodontitis" (2019). Faculty, Staff and Student Publications. 42.
https://digitalcommons.library.tmc.edu/uthdb_docs/42