Systemic Antibiotic Therapy Reduces Circulating Inflammatory Dendritic Cells and Treg-Th17 Plasticity in Periodontitis.

Authors

Mythilypriya Rajendran
Stephen Looney
Nagendra Singh
Mahmoud Elashiry
Mohamed M Meghil
Ahmed R El-Awady
Omnia Tawfik
Cristiano Susin
Roger M Arce
Christopher W Cutler

Publication Date

5-1-2019

Journal

Journal of Immunology

Abstract

Periodontitis (PD) is a common dysbiotic inflammatory disease that leads to local bone deterioration and tooth loss. PD patients experience low-grade bacteremias with oral microbes implicated in the risk of heart disease, cancer, and kidney failure. Although Th17 effectors are vital to fighting infection, functional imbalance of Th17 effectors and regulatory T cells (Tregs) promote inflammatory diseases. In this study, we investigated, in a small pilot randomized clinical trial, whether expansion of inflammatory blood myeloid dendritic cells (DCs) and conversion of Tregs to Th17 cells could be modulated with antibiotics (AB) as part of initial therapy in PD patients. PD patients were randomly assigned to either 7 d of peroral metronidazole/amoxicillin AB treatment or no AB, along with standard care debridement and chlorhexidine mouthwash. 16s ribosomal RNA analysis of keystone pathogen

Keywords

Amoxicillin, Bacteria, Bacterial Infections, Dendritic Cells, Female, Humans, Male, Metronidazole, Middle Aged, Periodontitis, T-Lymphocytes, Regulatory, Th17 Cells

Recommended Citation

Rajendran, Mythilypriya; Looney, Stephen; Singh, Nagendra; Elashiry, Mahmoud; Meghil, Mohamed M; El-Awady, Ahmed R; Tawfik, Omnia; Susin, Cristiano; Arce, Roger M; and Cutler, Christopher W, "Systemic Antibiotic Therapy Reduces Circulating Inflammatory Dendritic Cells and Treg-Th17 Plasticity in Periodontitis." (2019). Journal Articles. 42.
https://digitalcommons.library.tmc.edu/uthdb_docs/42