Increased Resolvin E1 Production by Peripheral Blood Mononuclear Cells in Periodontitis Patients: Pilot Study

Authors

Language

English

Publication Date

1-1-2024

Journal

Brazilian Dental Journal

DOI

10.1590/0103-6440202405861

PMID

39476108

PMCID

PMC11506237

PubMedCentral® Posted Date

10-25-2024

PubMedCentral® Full Text Version

Post-print

Abstract

This study quantified the production of the pro-resolving agent Resolvin E1 by peripheral blood mononuclear cells (PBMC) from 20 systemically healthy volunteers with and without periodontitis after stimulation with lipopolysaccharide (LPS) from Porphyromonas gingivalis (Pg). Ten periodontitis patients and 10 healthy volunteers (30-50 years old), matched by age and sex, were recruited. Peripheral blood mononuclear cells were isolated and stimulated in culture plates for 24 hours with Pg LPS. Resolvin E1 levels were measured in the supernatants by enzyme-linked immunosorbent assay. Significantly higher production of Resolvin E1 was observed in both groups when stimulated with LPS compared to baseline levels (p

Keywords

Humans, Pilot Projects, Leukocytes, Mononuclear, Adult, Male, Periodontitis, Female, Middle Aged, Eicosapentaenoic Acid, Lipopolysaccharides, Enzyme-Linked Immunosorbent Assay, Case-Control Studies, Porphyromonas gingivalis, Leukocytes Mononuclear cells, Periodontitis, Pro-resolving lipid mediators, Trained innate immunity

Published Open-Access

yes

Recommended Citation

, "Increased Resolvin E1 Production by Peripheral Blood Mononuclear Cells in Periodontitis Patients: Pilot Study" (2024). Faculty, Staff and Student Publications. 50.
https://digitalcommons.library.tmc.edu/uthdb_docs/50