Faculty, Staff and Student Publications
Publication Date
1-1-2024
Journal
Brazilian Dental Journal
Abstract
This study quantified the production of the pro-resolving agent Resolvin E1 by peripheral blood mononuclear cells (PBMC) from 20 systemically healthy volunteers with and without periodontitis after stimulation with lipopolysaccharide (LPS) from Porphyromonas gingivalis (Pg). Ten periodontitis patients and 10 healthy volunteers (30-50 years old), matched by age and sex, were recruited. Peripheral blood mononuclear cells were isolated and stimulated in culture plates for 24 hours with Pg LPS. Resolvin E1 levels were measured in the supernatants by enzyme-linked immunosorbent assay. Significantly higher production of Resolvin E1 was observed in both groups when stimulated with LPS compared to baseline levels (p
Keywords
Humans, Pilot Projects, Leukocytes, Mononuclear, Adult, Male, Periodontitis, Female, Middle Aged, Eicosapentaenoic Acid, Lipopolysaccharides, Enzyme-Linked Immunosorbent Assay, Case-Control Studies, Porphyromonas gingivalis, Leukocytes Mononuclear cells, Periodontitis, Pro-resolving lipid mediators, Trained innate immunity
DOI
10.1590/0103-6440202405861
PMID
39476108
PMCID
PMC11506237
PubMedCentral® Posted Date
10-25-2024
PubMedCentral® Full Text Version
Post-print
Recommended Citation
Suárez, Lina J; González-Duarte, Wilmer; Torrez-Velasco, Rodrigo; Salinas, Viviana; Roa-Molina, Nelly S; Muñoz, Sindy M; Rodríguez, Luz-Stella; Arce, Roger M; Shibli, Jamil A; and Rodríguez-Ciodaro, Adriana, "Increased Resolvin E1 Production by Peripheral Blood Mononuclear Cells in Periodontitis Patients: Pilot Study" (2024). Faculty, Staff and Student Publications. 50.
https://digitalcommons.library.tmc.edu/uthdb_docs/50
Graphical Abstract
Published Open-Access
yes
