Associations Between Metabolic Disorders and Sjögren’s Disease

Authors

Chihiro Iwaya
Junichi Iwata

Publication Date

12-1-2024

Journal

Japanese Dental Science Review

Abstract

Sjögren’s disease (SjD) is a systemic autoimmune disorder characterized by dry eyes and mouth caused by chronic inflammation and is often accompanied by various extra-glandular manifestations, including fatigue and diffuse pain. Although the pathogenesis of the disease remains elusive, several factors (e.g. environmental, genetic and hormonal factors, abnormal metabolic status) are associated with this condition. Accumulating evidence suggests a potential role of cholesterol metabolism in immune and non-immune modulation in various diseases. In this review, we summarize the current findings on the associations between cholesterol metabolism and SjD.

Keywords

Sjögren's disease, Cholesterol metabolism, Metabolic disorders, Autoimmune disorders

DOI

10.1016/j.jdsr.2024.06.002

PMID

39502167

PMCID

PMC11535258

PubMedCentral® Posted Date

10-21-2024

PubMedCentral® Full Text Version

Post-print

Recommended Citation

Iwaya, Chihiro and Iwata, Junichi, "Associations Between Metabolic Disorders and Sjögren’s Disease" (2024). Faculty, Staff and Student Publications. 65.
https://digitalcommons.library.tmc.edu/uthdb_docs/65

Published Open-Access

yes