NMR Spectroscopy-Based Metabolomics of Platelets to Analyze Brain Tumors.

Authors

Shivanand Pudakalakatti
Alessandra Audia
Anirudh Mukhopadhyay
José S Enriquez
Dontrey Bourgeois
Nabihah Tayob
Niki M Zacharias
Steven W Millward
Daniel Carson
Mary C Farach-Carson
Frederick F Lang
Amy B Heimberger
Krishna P Bhat
Pratip K Bhattacharya

Publication Date

12-1-2021

Journal

Reports

Abstract

"Tumor-educated platelets" have recently generated substantial interest for the diagnosis of cancer. We hypothesized that tumor educated platelets from patients with brain tumors will reflect altered metabolism compared to platelets from healthy volunteers. Here, in a pilot study, we have employed nuclear magnetic resonance (NMR) spectroscopy in platelets from brain tumor patients to demonstrate altered metabolism compared to the platelets obtained from healthy volunteers.

Keywords

Nspectroscopy, biomarkers, brain tumor, metabolomics, platelets

DOI

10.3390/reports4040032

PMID

35937580

PMCID

PMC9352435

PubMedCentral® Posted Date

8-4-2024

PubMedCentral® Full Text Version

Author MSS

Recommended Citation

Pudakalakatti, Shivanand; Audia, Alessandra; Mukhopadhyay, Anirudh; Enriquez, José S; Bourgeois, Dontrey; Tayob, Nabihah; Zacharias, Niki M; Millward, Steven W; Carson, Daniel; Farach-Carson, Mary C; Lang, Frederick F; Heimberger, Amy B; Bhat, Krishna P; and Bhattacharya, Pratip K, "NMR Spectroscopy-Based Metabolomics of Platelets to Analyze Brain Tumors." (2021). Faculty, Staff and Student Publications. 66.
https://digitalcommons.library.tmc.edu/uthdb_docs/66

Published Open-Access

yes