Faculty, Staff and Student Publications
Publication Date
11-26-2020
Journal
International Journal of Molecular Sciences
Abstract
Carbohydrates, fats, and proteins are the underlying energy sources for animals and are catabolized through specific biochemical cascades involving numerous enzymes. The catabolites and metabolites in these metabolic pathways are crucial for many cellular functions; therefore, an imbalance and/or dysregulation of these pathways causes cellular dysfunction, resulting in various metabolic diseases. Bone, a highly mineralized organ that serves as a skeleton of the body, undergoes continuous active turnover, which is required for the maintenance of healthy bony components through the deposition and resorption of bone matrix and minerals. This highly coordinated event is regulated throughout life by bone cells such as osteoblasts, osteoclasts, and osteocytes, and requires synchronized activities from different metabolic pathways. Here, we aim to provide a comprehensive review of the cellular metabolism involved in bone development and homeostasis, as revealed by mouse genetic studies.
Keywords
Animals, Bone Development, Homeostasis, Humans, Metabolic Networks and Pathways, Metabolism, Models, Biological, bone, metabolism, bone formation, bone homeostasis
DOI
10.3390/ijms21238992
PMID
33256181
PMCID
PMC7729585
PubMedCentral® Posted Date
11-26-2020
PubMedCentral® Full Text Version
Post-print
Recommended Citation
Suzuki, Akiko; Minamide, Mina; Iwaya, Chihiro; Ogata, Kenichi; and Iwata, Junichi, "Role of Metabolism in Bone Development and Homeostasis" (2020). Faculty, Staff and Student Publications. 70.
https://digitalcommons.library.tmc.edu/uthdb_docs/70
Published Open-Access
yes
