Role of Metabolism in Bone Development and Homeostasis

Authors

Language

English

Publication Date

11-26-2020

Journal

International Journal of Molecular Sciences

DOI

10.3390/ijms21238992

PMID

33256181

PMCID

PMC7729585

PubMedCentral® Posted Date

11-26-2020

PubMedCentral® Full Text Version

Post-print

Abstract

Carbohydrates, fats, and proteins are the underlying energy sources for animals and are catabolized through specific biochemical cascades involving numerous enzymes. The catabolites and metabolites in these metabolic pathways are crucial for many cellular functions; therefore, an imbalance and/or dysregulation of these pathways causes cellular dysfunction, resulting in various metabolic diseases. Bone, a highly mineralized organ that serves as a skeleton of the body, undergoes continuous active turnover, which is required for the maintenance of healthy bony components through the deposition and resorption of bone matrix and minerals. This highly coordinated event is regulated throughout life by bone cells such as osteoblasts, osteoclasts, and osteocytes, and requires synchronized activities from different metabolic pathways. Here, we aim to provide a comprehensive review of the cellular metabolism involved in bone development and homeostasis, as revealed by mouse genetic studies.

Keywords

Animals, Bone Development, Homeostasis, Humans, Metabolic Networks and Pathways, Metabolism, Models, Biological, bone, metabolism, bone formation, bone homeostasis

Published Open-Access

yes

Recommended Citation

, "Role of Metabolism in Bone Development and Homeostasis" (2020). Faculty, Staff and Student Publications. 70.
https://digitalcommons.library.tmc.edu/uthdb_docs/70