Faculty, Staff and Student Publications
Language
English
Publication Date
5-17-2022
Journal
Scientific Reports
DOI
10.1038/s41598-022-11965-4
PMID
35581227
PMCID
PMC9114112
PubMedCentral® Posted Date
5-17-2022
PubMedCentral® Full Text Version
Post-print
Abstract
High-resolution computed tomography (CT) is widely used to assess bone structure under physiological and pathological conditions. Although the analytic protocols and parameters for micro-CT (μCT) analyses in mice are standardized for long bones, vertebrae, and the palms in aging mice, they have not yet been established for craniofacial bones. In this study, we conducted a morphometric assessment of craniofacial bones, in comparison with long bones, in aging mice. Although age-related changes were observed in the microarchitecture of the femur, tibia, vertebra, and basisphenoid bone, and were more pronounced in females than in males, the microarchitecture of both the interparietal bone and body of the mandible, which develop by intramembranous ossification, was less affected by age and sex. By contrast, the condyle of the mandible was more affected by aging in males compared to females. Taken together, our results indicate that mouse craniofacial bones are uniquely affected by age and sex.
Keywords
Aging, Animals, Bone Density, Female, Femur, Male, Mice, Skull, X-Ray Microtomography
Published Open-Access
yes
Recommended Citation
, "Micro-computed Tomography Assessment of Bone Structure in Aging Mice" (2022). Faculty, Staff and Student Publications. 78.
https://digitalcommons.library.tmc.edu/uthdb_docs/78