Dance of The Golgi: Understanding Golgi Dynamics in Cancer Metastasis

Authors

Rakhee Bajaj
Amanda N Warner
Jared F Fradette
Don L Gibbons

Publication Date

4-28-2022

Journal

Cells

Abstract

The Golgi apparatus is at the center of protein processing and trafficking in normal cells. Under pathological conditions, such as in cancer, aberrant Golgi dynamics alter the tumor microenvironment and the immune landscape, which enhances the invasive and metastatic potential of cancer cells. Among these changes in the Golgi in cancer include altered Golgi orientation and morphology that contribute to atypical Golgi function in protein trafficking, post-translational modification, and exocytosis. Golgi-associated gene mutations are ubiquitous across most cancers and are responsible for modifying Golgi function to become pro-metastatic. The pharmacological targeting of the Golgi or its associated genes has been difficult in the clinic; thus, studying the Golgi and its role in cancer is critical to developing novel therapeutic agents that limit cancer progression and metastasis. In this review, we aim to discuss how disrupted Golgi function in cancer cells promotes invasion and metastasis.

Keywords

Golgi Apparatus, Humans, Neoplasms, Protein Transport, Tumor Microenvironment

DOI

10.3390/cells11091484

PMID

35563790

PMCID

PMC9102947

PubMedCentral® Posted Date

4-28-2022

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes