Faculty, Staff and Student Publications

Publication Date

12-1-2024

Journal

Precision Radiation Oncology

Abstract

Previously, a synchrotron-based horizontal proton beamline (87.2 MeV) was successfully commissioned to deliver radiation doses in FLASH and conventional dose rate modes to small fields and volumes. In this study, we developed a strategy to increase the effective radiation field size using a custom robotic motion platform to automatically shift the positions of biological samples. The beam was first broadened with a thin tungsten scatterer and shaped by customized brass collimators for irradiating cell/organoid cultures in 96-well plates (a 7-mm-diameter circle) or for irradiating mice (1-cm

Keywords

proton therapy, ultra‐high dose rate FLASH, robotic motion technique

DOI

10.1002/pro6.1243

PMID

40337456

PMCID

PMC11934911

PubMedCentral® Posted Date

10-24-2024

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes

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