Pancreatic Cancer: Advances and Challenges

Authors

Christopher J Halbrook
Costas A Lyssiotis
Marina Pasca di Magliano
Anirban Maitra

Publication Date

4-13-2023

Journal

Cell

Abstract

Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers. Significant efforts have largely defined major genetic factors driving PDAC pathogenesis and progression. Pancreatic tumors are characterized by a complex microenvironment that orchestrates metabolic alterations and supports a milieu of interactions among various cell types within this niche. In this review, we highlight the foundational studies that have driven our understanding of these processes. We further discuss the recent technological advances that continue to expand our understanding of PDAC complexity. We posit that the clinical translation of these research endeavors will enhance the currently dismal survival rate of this recalcitrant disease.

Keywords

Humans, Carcinoma, Pancreatic Ductal, Pancreatic Neoplasms, Tumor Microenvironment, Early Diagnosis, Prognosis

DOI

10.1016/j.cell.2023.02.014

PMID

37059070

PMCID

PMC10182830

PubMedCentral® Posted Date

4-13-2024

PubMedCentral® Full Text Version

Author MSS

Published Open-Access

yes