Faculty, Staff and Student Publications

Authors

Chowdhury Arif Jahangir
David B Page
Glenn Broeckx
Claudia A Gonzalez
Caoimbhe Burke
Clodagh Murphy
Jorge S Reis-Filho
Amy Ly
Paul W Harms
Rajarsi R Gupta
Michael Vieth
Akira I Hida
Mohamed Kahila
Zuzana Kos
Paul J van Diest
Sara Verbandt
Jeppe Thagaard
Reena Khiroya
Khalid Abduljabbar
Gabriela Acosta Haab
Balazs Acs
Sylvia Adams
Jonas S Almeida
Isabel Alvarado-Cabrero
Farid Azmoudeh-Ardalan
Sunil Badve
Nurkhairul Bariyah Baharun
Enrique R Bellolio
Vydehi Bheemaraju
Kim Rm Blenman
Luciana Botinelly Mendonça Fujimoto
Octavio Burgues
Alexandros Chardas
Maggie Chon U Cheang
Francesco Ciompi
Lee Ad Cooper
An Coosemans
Germán Corredor
Flavio Luis Dantas Portela
Frederik Deman
Sandra Demaria
Sarah N Dudgeon
Mahmoud Elghazawy
Claudio Fernandez-Martín
Susan Fineberg
Stephen B Fox
Jennifer M Giltnane
Sacha Gnjatic
Paula I Gonzalez-Ericsson
Anita Grigoriadis
Niels Halama
Matthew G Hanna
Aparna Harbhajanka
Steven N Hart
Johan Hartman
Stephen Hewitt
Hugo M Horlings
Zaheed Husain
Sheeba Irshad
Emiel Am Janssen
Tatsuki R Kataoka
Kosuke Kawaguchi
Andrey I Khramtsov
Umay Kiraz
Pawan Kirtani
Liudmila L Kodach
Konstanty Korski
Guray Akturk
Ely Scott
Anikó Kovács
Anne-Vibeke Laenkholm
Corinna Lang-Schwarz
Denis Larsimont
Jochen K Lennerz
Marvin Lerousseau
Xiaoxian Li
Anant Madabhushi
Sai K Maley
Vidya Manur Narasimhamurthy
Douglas K Marks
Elizabeth S McDonald
Ravi Mehrotra
Stefan Michiels
Durga Kharidehal
Fayyaz Ul Amir Afsar Minhas
Shachi Mittal
David A Moore
Shamim Mushtaq
Hussain Nighat
Thomas Papathomas
Frederique Penault-Llorca
Rashindrie D Perera
Christopher J Pinard
Juan Carlos Pinto-Cardenas
Giancarlo Pruneri
Lajos Pusztai
Nasir Mahmood Rajpoot
Bernardo Leon Rapoport
Tilman T Rau
Joana M Ribeiro
David Rimm
Anne Vincent-Salomon
Joel Saltz
Shahin Sayed
Evangelos Hytopoulos
Sarah Mahon
Kalliopi P Siziopikou
Christos Sotiriou
Albrecht Stenzinger
Maher A Sughayer
Daniel Sur
Fraser Symmans
Sunao Tanaka
Timothy Taxter
Sabine Tejpar
Jonas Teuwen
E Aubrey Thompson
Trine Tramm
William T Tran
Jeroen van der Laak
Gregory E Verghese
Giuseppe Viale
Noorul Wahab
Thomas Walter
Yannick Waumans
Hannah Y Wen
Wentao Yang
Yinyin Yuan
John Bartlett
Sibylle Loibl
Carsten Denkert
Peter Savas
Sherene Loi
Elisabeth Specht Stovgaard
Roberto Salgado
William M Gallagher
Arman Rahman

Publication Date

3-1-2024

Journal

The Journal of Pathology

Abstract

Recent advances in the field of immuno-oncology have brought transformative changes in the management of cancer patients. The immune profile of tumours has been found to have key value in predicting disease prognosis and treatment response in various cancers. Multiplex immunohistochemistry and immunofluorescence have emerged as potent tools for the simultaneous detection of multiple protein biomarkers in a single tissue section, thereby expanding opportunities for molecular and immune profiling while preserving tissue samples. By establishing the phenotype of individual tumour cells when distributed within a mixed cell population, the identification of clinically relevant biomarkers with high-throughput multiplex immunophenotyping of tumour samples has great potential to guide appropriate treatment choices. Moreover, the emergence of novel multi-marker imaging approaches can now provide unprecedented insights into the tumour microenvironment, including the potential interplay between various cell types. However, there are significant challenges to widespread integration of these technologies in daily research and clinical practice. This review addresses the challenges and potential solutions within a structured framework of action from a regulatory and clinical trial perspective. New developments within the field of immunophenotyping using multiplexed tissue imaging platforms and associated digital pathology are also described, with a specific focus on translational implications across different subtypes of cancer. © 2024 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.

Keywords

Humans, Female, Breast Neoplasms, Biomarkers, Tumor, Prognosis, Phenotype, United Kingdom, Tumor Microenvironment

DOI

10.1002/path.6238

PMID

38230434

PMCID

PMC11288342

PubMedCentral® Posted Date

7-30-2024

PubMedCentral® Full Text Version

Author MSS

Published Open-Access

yes

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