Student and Faculty Publications
Publication Date
1-6-2023
Journal
Nucleic Acids Research
Abstract
PICKLES (https://pickles.hart-lab.org) is an updated web interface to a freely available database of genome-scale CRISPR knockout fitness screens in human cell lines. Using a completely rewritten interface, researchers can explore gene knockout fitness phenotypes across cell lines and tissue types and compare fitness profiles with fitness, expression, or mutation profiles of other genes. The database has been updated to include data from three CRISPR libraries (Avana, Score, and TKOv3), and includes information from 1162 whole-genome screens probing the knockout fitness phenotype of 18 959 genes. Source code for the interface and the integrated database are available for download.
Keywords
Humans, Clustered Regularly Interspaced Short Palindromic Repeats, CRISPR-Cas Systems, Gene Knockout Techniques, Gene Library, Genome, Databases, Genetic, Cell Line
Included in
Bioinformatics Commons, Biomedical Informatics Commons, Medical Sciences Commons, Oncology Commons
Comments
PMID: 36350677