Faculty, Staff and Student Publications
Proton Magnetic Resonance Spectroscopy in Multiple Sclerosis
Publication Date
2-1-2009
Journal
Neuroimaging Clinics of North America
Abstract
Proton magnetic resonance spectroscopy ((1)H-MRS) provides tissue metabolic information in vivo. This article reviews the role of MRS-determined metabolic alterations in lesions, normal-appearing white matter, gray matter, and spinal cord in advancing our knowledge of pathologic changes in multiple sclerosis (MS). In addition, the role of MRS in objectively evaluating therapeutic efficacy is reviewed. This potential metabolic information makes MRS a unique tool to follow MS disease evolution, understand its pathogenesis, evaluate the disease severity, establish a prognosis, and objectively evaluate the efficacy of therapeutic interventions.
Keywords
Brain, Humans, Magnetic Resonance Spectroscopy, Multiple Sclerosis
DOI
10.1016/j.nic.2008.08.002
PMID
19064199
PMCID
PMC2615006
PubMedCentral® Posted Date
February 2010
PubMedCentral® Full Text Version
Author MSS
Published Open-Access
yes