Detecting Primary Progressive Aphasia Atrophy Patterns: A Comparison of Visual Assessment and Quantitative Neuroimaging Techniques

Authors

Stephanie Franczak
Jessica Pommy
Greta Minor
Chandler Zolliecoffer
Manav Bhalla
Mohit Agarwal
Andrew Nencka
Yang Wang
Andrew Klein
Darren O'Neill
Jude Henry
Glass Umfleet

Publication Date

1-1-2022

Journal

Journal of Alzheimer's Disease Reports

Abstract

BACKGROUND: There are now clinically available automated MRI analysis software programs that compare brain volumes of patients to a normative sample and provide

OBJECTIVE: To address this gap in the literature, we examined Neuroreader

METHODS: lvPPA or aMCI patients who underwent MRI with Neuroreader

RESULTS: Cohen's Kappa coefficients were significant in 10 of the 28 computations (

CONCLUSION: Overall, our results indicated moderate to low interrater reliability, and raters never agreed that left asymmetry was present. While lower

Keywords

Logopenic variant PPA, magnetic resonance imaging, mild cognitive impairment, neuroreader