Systemic Inflammatory Markers of Persistent Cerebral Edema After Aneurysmal Subarachnoid Hemorrhage

Authors

Nadia Khan
Magdalena Kurnik-Łucka
Gniewomir Latacz
Krzysztof Gil

Publication Date

5-20-2024

Journal

International Journal of Molecular Sciences

Abstract

In the first part of this article, the role of intestinal epithelial tight junctions (TJs), together with gastrointestinal dopaminergic and renin-angiotensin systems, are narratively reviewed to provide sufficient background. In the second part, the current experimental data on the interplay between gastrointestinal (GI) dopaminergic and renin-angiotensin systems in the regulation of intestinal epithelial permeability are reviewed in a systematic manner using the PRISMA methodology. Experimental data confirmed the copresence of DOPA decarboxylase (DDC) and angiotensin converting enzyme 2 (ACE2) in human and rodent enterocytes. The intestinal barrier structure and integrity can be altered by angiotensin (1-7) and dopamine (DA). Both renin-angiotensin and dopaminergic systems influence intestinal Na

Keywords

Humans, Renin-Angiotensin System, Dopamine, Animals, Tight Junctions, Intestinal Mucosa, Permeability, Gastrointestinal Tract, Intestinal Barrier Function

DOI

10.3390/ijms25105566

PMID

38791603

PMCID

PMC11122119

PubMedCentral® Posted Date

May 2024

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes