Faculty, Staff and Student Publications
Language
English
Publication Date
5-20-2024
Journal
International Journal of Molecular Sciences
DOI
10.3390/ijms25105566
PMID
38791603
PMCID
PMC11122119
PubMedCentral® Posted Date
May 2024
PubMedCentral® Full Text Version
Post-print
Abstract
In the first part of this article, the role of intestinal epithelial tight junctions (TJs), together with gastrointestinal dopaminergic and renin-angiotensin systems, are narratively reviewed to provide sufficient background. In the second part, the current experimental data on the interplay between gastrointestinal (GI) dopaminergic and renin-angiotensin systems in the regulation of intestinal epithelial permeability are reviewed in a systematic manner using the PRISMA methodology. Experimental data confirmed the copresence of DOPA decarboxylase (DDC) and angiotensin converting enzyme 2 (ACE2) in human and rodent enterocytes. The intestinal barrier structure and integrity can be altered by angiotensin (1-7) and dopamine (DA). Both renin-angiotensin and dopaminergic systems influence intestinal Na
Keywords
Humans, Renin-Angiotensin System, Dopamine, Animals, Tight Junctions, Intestinal Mucosa, Permeability, Gastrointestinal Tract, Intestinal Barrier Function
Published Open-Access
yes
Recommended Citation
Khan, Nadia; Kurnik-Łucka, Magdalena; Latacz, Gniewomir; et al., "Systemic Inflammatory Markers of Persistent Cerebral Edema After Aneurysmal Subarachnoid Hemorrhage" (2024). Faculty, Staff and Student Publications. 1107.
https://digitalcommons.library.tmc.edu/uthmed_docs/1107
Included in
Gastroenterology Commons, Hepatology Commons, Medical Molecular Biology Commons, Radiology Commons