Neuroprotective Activity of Enantiomers of Salsolinol and N-Methyl-(R)-salsolinol: In Vitro and In Silico Studies

Authors

Magdalena Kurnik-Łucka
Gniewomir Latacz
Adam Bucki
Mario Rivera-Meza
Nadia Khan
Jahnobi Konwar
Kamil Skowron
Marcin Kołaczkowski
Krzysztof Gil

Language

English

Publication Date

10-17-2023

Journal

American Chemical Society Omega

DOI

10.1021/acsomega.3c05527

PMID

37867702

PMCID

PMC10586258

PubMedCentral® Posted Date

October 2023

PubMedCentral® Full Text Version

Post-print

Abstract

Salsolinol (1-methyl-1,2,3,4-tetrahydroisoquinoline-6,7-diol) is a close structural analogue of dopamine with an asymmetric center at the C1 position, and its presence in vivo, both in humans and rodents, has already been proven. Yet, given the fact that salsolinol colocalizes with dopamine-rich regions and was first detected in the urine of Parkinson's disease patients, its direct role in the process of neurodegeneration has been proposed. Here, we report that

Published Open-Access

yes

Recommended Citation

Kurnik-Łucka, Magdalena; Latacz, Gniewomir; Bucki, Adam; et al., "Neuroprotective Activity of Enantiomers of Salsolinol and N-Methyl-(R)-salsolinol: In Vitro and In Silico Studies" (2023). Faculty, Staff and Student Publications. 1119.
https://digitalcommons.library.tmc.edu/uthmed_docs/1119