Characteristics of Early Pancreatic Cancer: Comparison between Stage 1A and Stage 1B Pancreatic Cancer in Multicenter Clinical Data Warehouse Study

Authors

Hyo Suk Kim
Young Hoon Choi
Jae Sin Lee
Ik Hyun Jo
Sung Woo Ko
Kyu Hyun Paik
Hyun Ho Choi
Han Hee Lee
Yeon Soo Lim
Chang Nyol Paik
In Seok Lee
Jae Hyuck Chang

Publication Date

2-26-2024

Journal

Cancers

Abstract

BACKGROUND: Little is known about the characteristics of early pancreatic cancer. We aimed to identify the characteristics, clues for early detection, and prognostic factors for early pancreatic cancer by analyzing a large number of patients with stage 1 pancreatic cancer.

METHODS: A clinical data warehouse that includes databases of all the medical records of eight academic institutions was used to select and analyze patients with pancreatic cancer that had been diagnosed from January 2010 to May 2023.

RESULTS: In total, 257 stage 1 pancreatic cancer patients were included. There were 134 men (52%), and the average age was 67.2 ± 9.9 years. Compared to patients with stage 1B pancreatic cancer (2-4 cm), patients with stage 1A pancreatic cancer (≤2 cm) had more tumors in the body and tail than in the head (

CONCLUSIONS: IPMN is closely associated with early pancreatic cancer and may provide an opportunity for early detection. The presence of perineural invasion was a crucial prognostic factor for both overall and disease-free survival in patients with stage 1 pancreatic cancer.

Keywords

early detection of cancer, pancreatic cancer, pancreatic intraductal neoplasm, prognosis, survival