Expression and Functions of Transient Receptor Potential Channels in Liver Diseases

Authors

Wenhui Wang
Pengyu Liu
Yalin Zhang
Li Yan
Michael X Zhu
Jin Wang
Ye Yu

Language

English

Publication Date

2-1-2023

Journal

Acta Pharmaceutica Sinica B

DOI

10.1016/j.apsb.2022.09.005

PMID

36873177

PMCID

PMC9978971

PubMedCentral® Posted Date

9-15-2022

PubMedCentral® Full Text Version

Post-print

Abstract

Liver diseases constitute a major healthcare burden globally, including acute hepatic injury resulted from acetaminophen overdose, ischemia-reperfusion or hepatotropic viral infection and chronic hepatitis, alcoholic liver disease (ALD), non-alcoholic fatty liver disease (NAFLD) and hepatocellular carcinoma (HCC). Attainable treatment strategies for most liver diseases remain inadequate, highlighting the importance of substantial pathogenesis. The transient receptor potential (TRP) channels represent a versatile signalling mechanism regulating fundamental physiological processes in the liver. It is not surprising that liver diseases become a newly explored field to enrich our knowledge of TRP channels. Here, we discuss recent findings revealing TRP functions across the fundamental pathological course from early hepatocellular injury caused by various insults, to inflammation, subsequent fibrosis and hepatoma. We also explore expression levels of TRPs in liver tissues of ALD, NAFLD and HCC patients from Gene Expression Omnibus (GEO) or The Cancer Genome Atlas (TCGA) database and survival analysis estimated by Kaplan-Meier Plotter. At last, we address the therapeutical potential and challenges by pharmacologically targeting TRPs to treat liver diseases. The aim is to provide a better understanding of the implications of TRP channels in liver diseases, contributing to the discovery of novel therapeutic targets and efficient drugs.

Keywords

TRP, Liver disease, Liver injury, ALD, NAFLD, Fibrosis, Inflammation, HCC

Published Open-Access

yes

Recommended Citation

Wang, Wenhui; Liu, Pengyu; Zhang, Yalin; et al., "Expression and Functions of Transient Receptor Potential Channels in Liver Diseases" (2023). Faculty, Staff and Student Publications. 1268.
https://digitalcommons.library.tmc.edu/uthmed_docs/1268