Decoding the Molecular Symphony: Interactions Between the m6A and p53 Signaling Pathways in Cancer

Authors

Rachel Shoemaker
Mo-Fan Huang
Ying-Si Wu
Cheng-Shuo Huang
Dung-Fang Lee

Language

English

Publication Date

9-1-2024

Journal

NAR Cancer

DOI

10.1093/narcan/zcae037

PMID

39329012

PMCID

PMC11426327

PubMedCentral® Posted Date

9-26-2024

PubMedCentral® Full Text Version

Post-print

Abstract

The p53 tumor suppressor gene governs a multitude of complex cellular processes that are essential for anti-cancer function and whose dysregulation leads to aberrant gene transcription, activation of oncogenic signaling and cancer development. Although mutations can occur at any point in the genetic sequence, missense mutations comprise the majority of observed p53 mutations in cancers regardless of whether the mutation is germline or somatic. One biological process involved in both mutant and wild-type p53 signaling is the N6-methyladenosine (m6A) epitranscriptomic network, a type of post-transcriptional modification involved in over half of all eukaryotic mRNAs. Recently, a significant number of findings have demonstrated unique interactions between p53 and the m6A epitranscriptomic network in a variety of cancer types, shedding light on a previously uncharacterized connection that causes significant dysregulation. Cross-talk between wild-type or mutant p53 and the m6A readers, writers and erasers has been shown to impact cellular function and induce cancer formation by influencing various cancer hallmarks. Here, this review aims to summarize the complex interplay between the m6A epitranscriptome and p53 signaling pathway, highlighting its effects on tumorigenesis and other hallmarks of cancer, as well as identifying its therapeutic implications for the future.

Published Open-Access

yes

Recommended Citation

Shoemaker, Rachel; Huang, Mo-Fan; Wu, Ying-Si; et al., "Decoding the Molecular Symphony: Interactions Between the m6A and p53 Signaling Pathways in Cancer" (2024). Faculty, Staff and Student Publications. 1272.
https://digitalcommons.library.tmc.edu/uthmed_docs/1272