The Association of Intensive Blood Pressure Treatment and Non-Fatal Cardiovascular or Serious Adverse Events in Older Adults With Mortality: Mediation Analysis in SPRINT

Authors

Adil A Ali
Khalid E Khalid
Hajir M Hussien
Somaya E Mohammed
Osman K Saeed

Language

English

Publication Date

8-1-2023

Journal

Cureus

DOI

10.7759/cureus.43905

PMID

37746389

PMCID

PMC10512431

PubMedCentral® Posted Date

August 2023

PubMedCentral® Full Text Version

Post-print

Abstract

INTRODUCTION: Human leukocyte antigens (HLA) account for up to one-half of the total genetic contribution to rheumatoid arthritis (RA) risk. The study investigated the association of HLA class II genotyping with RA susceptibility in Sudanese ethnic groups.

METHODS: The DRB1 and DQB1 alleles and haplotypes were determined in 122 RA patients (i.e., Gaalia = 54, Johayna = 24, Baggara = 17, Nile Nubian = 12, and others = 15) and 120 healthy controls of ethnic groups (i.e., Gaalia = 44, Johayna = 11, Baggara = 15, Nile Nubian = 9, and others = 21) using a polymerase chain reaction with sequence-specific primers method.

RESULTS: Susceptibility to RA was associated with a high frequency of DRB1*04 (P = 0.04), DRB1*10 (P = 0.04), and DQB1*03 (P = 2.2 x 10

CONCLUSIONS: Our findings indicate an association between HLA-DRB1 and DQB1 genotypes and the susceptibility to RA in the Sudanese population, with a moderate frequency between our ethnic groups.

Keywords

human leukocyte antigen, rheumatoid factor, anti-ccp, hla-dqb1, hla-drb1, rheumatoid arthritis

Published Open-Access

yes

Recommended Citation

Ali, Adil A; Khalid, Khalid E; Hussien, Hajir M; et al., "The Association of Intensive Blood Pressure Treatment and Non-Fatal Cardiovascular or Serious Adverse Events in Older Adults With Mortality: Mediation Analysis in SPRINT" (2023). Faculty, Staff and Student Publications. 1462.
https://digitalcommons.library.tmc.edu/uthmed_docs/1462