Publication Date
3-1-2006
Journal
Drug Metab Dispos. Author manuscript; available in PMC 2007 March 1.
Abstract
Citrobacter rodentium is the rodent equivalent of human enteropathogenic Escherichia coli infection. This study investigated regulation of hepatic and renal cytochrome P450 (P450) mRNAs, hepatic P450 proteins, cytokines, and acute phase proteins during C. rodentium infection. Female C3H/HeOuJ (HeOu) and C3H/HeJ (HeJ) mice [which lack functional toll-like receptor 4 (TLR4)] were infected with C. rodentium by oral gavage and sacrificed 6 days later. Hepatic CYP4A10 and 4A14 mRNAs were decreased in HeOu mice (
Keywords
Animals, Blotting, Western, Citrobacter rodentium, Cytochrome P-450 Enzyme System, Enterobacteriaceae Infections, Female, Gene Expression Regulation, Enzymologic, Kidney, Liver, Mice, Mice, Mutant Strains, Mutation, Reverse Transcriptase Polymerase Chain Reaction, Toll-Like Receptor 4