Pulvinar Neuromodulation for Seizure Monitoring and Network Modulation in Temporal Plus Epilepsy

Authors

Yash Shashank Vakilna
Ganne Chaitanya
Muhammad Ubaid Hafeez
Adeel Ilyas
Manojkumar Saranathan
Jay Gavvala
Nitin Tandon
Sandipan Pati

Publication Date

7-1-2023

Journal

Annals of Clinical and Translational Neurology

Abstract

Deep brain stimulation (DBS) is a promising treatment for drug-refractory epilepsies (DRE) when targeting the anterior nuclei of thalamus (ANT). However, targeting other thalamic nuclei, such as the pulvinar, shows therapeutic promise. Our pioneering case study presents the application of ambulatory seizure monitoring using spectral fingerprinting (12.15-17.15 Hz) recorded through Medtronic Percept DBS implanted bilaterally in the medial pulvinar thalami. This technology offers unprecedented opportunities for real-time monitoring of seizure burden and thalamocortical network modulation for effective seizure reduction in patients with bilateral mesial temporal and temporal plus epilepsies that are not suitable for resection.

Keywords

Humans, Pulvinar, Deep Brain Stimulation, Electrodes, Implanted, Epilepsy, Seizures