Faculty, Staff and Student Publications

Language

English

Publication Date

9-29-2022

Journal

Neuro-Oncology Advances

DOI

10.1093/noajnl/vdac158

PMID

36325373

PMCID

PMC9616057

PubMedCentral® Posted Date

September 2022

PubMedCentral® Full Text Version

Post-print

Abstract

In IDH-wildtype glioblastomas which meet the histopathological or molecular diagnosis criteria, it remains unclear whether the presence of TERT promotor mutations provides additional prognostic information. Based on a multicenter cohort of 466 IDH-wildtype glioblastomas (including 396 with and 70 patients without TERT promotor mutations), we found that TERT promotor mutations were neither associated with progression-free survival nor overall survival. This held true in various treatment-based or molecular subgroups. This argues against standardized analysis for TERT promotor mutation status for the purpose of prognostic or therapeutic relevance in newly diagnosed IDH-wildtype glioblastoma that otherwise meets the histopathological and molecular diagnosis criteria.

Published Open-Access

yes

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