Genetic Loss of miR-205 Causes Increased Mammary Gland Development

Authors

Alessandra Cataldo
Douglas G Cheung
John P Hagan
Matteo Fassan
Sukhinder Sandhu-Deol
Carlo M Croce
Gianpiero Di Leva
Marilena V Iorio

Language

English

Publication Date

12-31-2023

Journal

Noncoding RNA

DOI

10.3390/ncrna10010004

PMID

38250804

PMCID

PMC10801544

PubMedCentral® Posted Date

December 2023

PubMedCentral® Full Text Version

Post-print

Abstract

MiRNAs play crucial roles in a broad spectrum of biological processes, both physiological and pathological. Different reports implicate miR-205 in the control of breast stem cell properties. Differential miR-205 expression has been observed in different stages of mammary gland development and maturation. However, a functional role in this process has not been clearly demonstrated. We generated an miR-205 knockout in the FVB/N mouse strain, which is viable and characterized by enhanced mammary gland development. Indeed, mammary glands of miR-205

Keywords

microRNA, mammary gland, breast cancer

Published Open-Access

yes

Recommended Citation

Cataldo, Alessandra; Cheung, Douglas G; Hagan, John P; et al., "Genetic Loss of miR-205 Causes Increased Mammary Gland Development" (2023). Faculty, Staff and Student Publications. 1643.
https://digitalcommons.library.tmc.edu/uthmed_docs/1643