EbpR is important for biofilm formation by activating expression of the endocarditis and biofilm-associated pilus operon (ebpABC) of Enterococcus faecalis OG1RF

Authors

Agathe Bourgogne
Kavindra V Singh
Kristina A Fox
Kathryn J Pflughoeft
Barbara E Murray
Danielle A Garsin

Publication Date

9-1-2007

Journal

Journal of Bacteriology

Abstract

We identify ef1090 (renamed ebpR) and show its importance for the transcriptional regulation of expression of the Enterococcus faecalis pilus operon, ebpABC. An ebpR deletion (DeltaebpR) mutant was found to have reduced ebpABC expression with loss of pilus production and a defect in primary adherence with, as a consequence, reduced biofilm formation.

Keywords

Bacterial Adhesion, Bacterial Proteins, Biofilms, Enterococcus faecalis, Fimbriae, Bacterial, Gene Deletion, Gene Expression Regulation, Bacterial, Operon, Transcription Factors