Synthesis, Biological Evaluation, and Molecular Modeling Studies of 1-Aryl-1H-pyrazole-Fused Curcumin Analogues as Anticancer Agents

Authors

Nam Q H Doan
Ngan T K Nguyen
Vu B Duong
Ha T T Nguyen
Long B Vong
Diem N Duong
Nguyet-Thu T Nguyen
Tuyen L T Nguyen
Tuoi T H Do
Tuyen N Truong

Publication Date

9-27-2022

Journal

ACS Omega

Abstract

Addressing the growing burden of cancer and the shortcomings of chemotherapy in cancer treatment are the current research goals. Research to overcome the limitations of curcumin and to improve its anticancer activity via its heterocycle-fused monocarbonyl analogues (MACs) has immense potential. In this study, 32 asymmetric MACs fused with 1-aryl-1