Local Ocular Safety of The Subconjunctival Injection of Cetuximab In Rabbits

Authors

Hossein Aghaei
Ahmad Kheirkhah
Ali Mohammad Alizadeh
Acieh Es'haghi
Roshanak Aliakbar-Navahi
Zahra Keikha
Samira Chaibakhsh

Publication Date

4-13-2023

Journal

BMC Ophthalmology

Abstract

BACKGROUND: To evaluate the safety of different doses of subconjunctival cetuximab in rabbits.

METHODS: After general anesthesia rabbits received a subconjunctival injection of 2.5 mg in 0.5 ml, 5 mg in 1 ml, and 10 mg in 2 ml of cetuximab in their right eyes (two rabbits in each group). A similar volume of normal saline solution was injected subconjunctivally in the left eyes. The histopathologic changes were evaluated after enucleation with the aid of H&E staining.

RESULTS: No significant difference were observed between the treated and control eyes in terms of conjunctival inflammation, goblet cell density, or limbal blood vessel density for all administered doses of cetuximab.

CONCLUSION: Subconjunctival injection of cetuximab with the administrated doses in rabbit eyes are safe.

Keywords

Ocular surface squamous neoplasia, Intraepithelial neoplasia, Cetuximab

Comments

PMID: 37055797

PMID

37055797

PubMedCentral® Full Text Version

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Published Open-Access

yes