Publication Date
4-13-2023
Journal
BMC Ophthalmology
Abstract
BACKGROUND: To evaluate the safety of different doses of subconjunctival cetuximab in rabbits.
METHODS: After general anesthesia rabbits received a subconjunctival injection of 2.5 mg in 0.5 ml, 5 mg in 1 ml, and 10 mg in 2 ml of cetuximab in their right eyes (two rabbits in each group). A similar volume of normal saline solution was injected subconjunctivally in the left eyes. The histopathologic changes were evaluated after enucleation with the aid of H&E staining.
RESULTS: No significant difference were observed between the treated and control eyes in terms of conjunctival inflammation, goblet cell density, or limbal blood vessel density for all administered doses of cetuximab.
CONCLUSION: Subconjunctival injection of cetuximab with the administrated doses in rabbit eyes are safe.
Keywords
Ocular surface squamous neoplasia, Intraepithelial neoplasia, Cetuximab
Comments
PMID: 37055797