Frosted Branch Angiitis After Smallpox Vaccination

Authors

Kristen Collister
Sam S Dahr

Language

English

Publication Date

9-1-2022

Journal

American Journal of Ophthalmology Case Reports

DOI

10.1016/j.ajoc.2022.101622

PMID

35880209

PMCID

PMC9307933

PubMedCentral® Posted Date

July 2022

PubMedCentral® Full Text Version

Post-print

Abstract

PURPOSE: To describe a patient presenting with frosted branch angiitis soon after small-pox vaccination.

OBSERVATIONS: Frosted branch angiitis (FBA) is an acute onset retinal vasculitis featuring prominent perivascular sheathing in otherwise healthy individuals. FBA has been associated with noninfectious and infectious etiologies. This report describes a twenty-year-old African American female who developed bilateral frosted branch angiitis one week after small-pox vaccination. At presentation, the patient had bilateral, para-central visual field defects and subjective visual disturbances. On dilated exam, the patient demonstrated diffuse vasculitis bilaterally. The patient's field defects and clinical exam responded dramatically to oral prednisone therapy.

CONCLUSIONS AND IMPORTANCE: Acute idiopathic frosted branch angiitis is a rare condition which was temporally associated with small-pox vaccination.

Keywords

Smallpox vaccine, Retinal vasculitis, Frosted branch angiitis, Uveitis, Inflammation

Published Open-Access

yes

Recommended Citation

Kristen Collister and Sam S Dahr, "Frosted Branch Angiitis After Smallpox Vaccination" (2022). Faculty, Staff and Student Publications. 1785.
https://digitalcommons.library.tmc.edu/uthmed_docs/1785