Povidone-Iodine Solution As SARS-CoV-2 Prophylaxis for Procedures of the Upper Aerodigestive Tract a Theoretical Framework

Authors

Syed H S Naqvi
Martin J Citardi
Davide Cattano
Luis Ostrosky-Zeichner
Mark I Knackstedt
Ron J Karni

Publication Date

10-27-2020

Journal

Journal of Otolaryngology - Head & Neck Surgery

Abstract

BACKGROUND: The COVID-19 pandemic has raised concerns of inadvertent SARS-CoV-2 transmission to healthcare workers during routine procedures of the aerodigestive tract in asymptomatic COVID-19 patients. Current efforts to mitigate this risk focus on Personal Protective Equipment, including high-efficiency filtration as well as other measures. Because the reservoir for SARS-CoV-2 shedding is in the nasopharynx and nasal and oral cavities, the application of viricidal agents to these surfaces may reduce virus burden. Numerous studies have confirmed that povidone-iodine inactivates many common respiratory viruses, including SARS-CoV-1. Povidone-iodine also has good profile for mucosal tolerance. Thus, we propose a prophylactic treatment protocol for the application of topical povidone-iodine to the upper aerodigestive tract.

CONCLUSION: Such an approach represents a low-cost, low-morbidity measure that may reduce the risks associated with aerosol-generating procedures performed commonly in otorhinolaryngology operating rooms.

Keywords

Povidone-iodine, Betadine, SARS-CoV-2, Prophylaxis, COVID-19, Upper Aerodigestive tract

Comments

PMID: 33109269