Guidance for Contemporary Use of Biologics in Management of Chronic Rhinosinusitis With Nasal Polyps: Discussion From a National Institutes of Health-Sponsored Workshop

Authors

Lauren T Roland
Timothy L Smith
Rodney J Schlosser
Zachary M Soler
Anju T Peters
Tanya M Laidlaw
Benjamin S Bleier
Vijay Ramakrishnan
Elina Toskala
David W Kennedy
Amber U Luong

Publication Date

9-1-2020

Journal

International Forum of Allergy & Rhinology

Abstract

BACKGROUND: Biologic medications are emerging as options for treating chronic rhinosinusitis with nasal polyps (CRSwNP). Several questions remain regarding patient selection, indications, clinical efficacy, and cost effectiveness.

METHODS: In November 2019, a group of physicians and scientists gathered to consider strategies for future studies regarding biologics. During the discussion, gaps in knowledge highlighted a need for a consensus on the present day use of biologics in polyp patients.

RESULTS: The goal of this guideline is to propose recommendations for the current use of biologics in CRSwNP as new evidence continues to emerge and inform practice.

CONCLUSION: We suggest that physicians evaluate patients on an individual basis and closely monitor for improvement due to the high cost and unknown long-term effects of biologics.

Keywords

chronic rhinosinusitis, medical therapy of chronic rhinosinusitis, endoscopic sinus surgery, topical therapy for chronic rhinosinusitis, guideline

Comments

PMID: 32484603