Low-Dose Immune Tolerance Induction In Children With Severe Hemophilia A With High-Titer Inhibitors: Type of Factor 8 Mutation and Outcomes

Authors

Jie Sun
Zekun Li
Gang Li
Kun Huang
Di Ai
Guoqing Liu
Wanru Yao
Xingjuan Xie
Hao Gu
Yingzi Zhen
Zhenping Chen
Runhui Wu

Publication Date

10-1-2022

Journal

Research and Practice in Thrombosis and Haemostasis

Abstract

BACKGROUND: No studies evaluated the role of

OBJECTIVES: To explore the association between

METHODS: Children SHA with high-titer inhibitors who received low-dose ITI therapy at least for 1 year were included in this study. Based on the risk of inhibitor development,

RESULTS: Of 104 children included, 101 had

CONCLUSIONS: Types of

Keywords

F8 mutation, high‐titer inhibitor, immune tolerance induction, low‐dose, predictor, severe hemophilia A

Comments

Supplementary Materials

PMID: 36313984

PMID

36313984

PMCID

PMC9606347

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes