Exploration of the Minimum Necessary FVIII Level at Different Physical Activity Levels in Pediatric Patients with Hemophilia A

Authors

Di Ai
Kun Huang
Gang Li
Yingzi Zhen
Xinyi Wu
Ningning Zhang
Aihua Huo
Zhenping Chen
Runhui Wu

Publication Date

11-1-2022

Journal

Frontiers in Pediatrics

Abstract

BACKGROUND: Physical activity can increase joint stability and reduce the risk of injury in hemophilia patients. There is limited clinical data on target trough FVIII levels during physical activity in hemophilia A patients. Hence, this study aimed to explore the target trough FVIII level required to avoid bleeding during different physical activities in hemophilia A patients.

METHODS: Patients with severe or moderate hemophilia A, who underwent pharmacokinetics (PK) tests at our center were enrolled in this study. Physical activities and clinical information such as bleeding were recorded. The FVIII level during physical activity was calculated by the WAPPS-Hemo.

RESULTS: A total of 105 patients were enrolled in this study. A total of 373 physical activities were recorded, of which 57.6% (215/373) was low-risk activities and the remaining 42.4% (158/373) was medium-risk activities. Most common physical activities were bicycling (59.0%), swimming (43.8%), running (48.6%), and jumping rope (41.0%). The FVIII trough level of low-risk physical activity was 3.8 IU/dl (AUC = 0.781,

CONCLUSION: The minimum necessary FVIII level increased with higher risk physical activity, irrespective of arthropathy.

Keywords

hemophilia A, children, physical activity, FVIII level, hemarthrosis

Comments

PMID: 36389359