Micrornas and Gene Regulatory Networks Related To Cleft Lip and Palate

Authors

Chihiro Iwaya
Akiko Suzuki
Junichi Iwata

Publication Date

2-10-2023

Journal

International Journal of Molecular Sciences

Abstract

Cleft lip and palate is one of the most common congenital birth defects and has a complex etiology. Either genetic or environmental factors, or both, are involved at various degrees, and the type and severity of clefts vary. One of the longstanding questions is how environmental factors lead to craniofacial developmental anomalies. Recent studies highlight non-coding RNAs as potential epigenetic regulators in cleft lip and palate. In this review, we will discuss microRNAs, a type of small non-coding RNAs that can simultaneously regulate expression of many downstream target genes, as a causative mechanism of cleft lip and palate in humans and mice.

Keywords

cleft lip, cleft palate, microRNA, craniofacial development, environmental factor

DOI

10.3390/ijms24043552

PMID

36834963

PMCID

PMC9958963

PubMedCentral® Posted Date

February 2023

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes