Surfactant Protein a Attenuates Generalized and Localized Neuroinflammation in Neonatal Mice

Authors

Caroline E Crocker
Romana Sharmeen
Thu T Tran
Amir M Khan
Wen Li
Joseph L Alcorn

Publication Date

5-15-2023

Journal

Brain Research

Abstract

Surfactant protein A (SP-A) has important roles in innate immunity and modulation of pulmonary and extrapulmonary inflammation. Given SP-A has been detected in rat and human brain, we sought to determine if SP-A has a role in modulating inflammation in the neonatal mouse brain. Neonatal wildtype (WT) and SP-A-deficient (SP-A

Keywords

Humans, Animals, Mice, Rats, Animals, Newborn, Pulmonary Surfactant-Associated Protein A, Neuroinflammatory Diseases, Inflammation, Cytokines, Sepsis

Comments

PMID: 36871846