A Comparison of Methods of Discontinuing Nasal Cpap In Premature Infants <30 Weeks Gestation: A Feasibility Study

Authors

Brittany Duyka
Claire Beaullieu
Amir M Khan

Publication Date

11-1-2021

Journal

Journal of Perinatology

Abstract

OBJECTIVE: The objective of this study was to determine whether abrupt discontinuation vs gradual wean of nasal CPAP (NCPAP) in infantstherapy.

STUDY DESIGN: We performed a single-center, randomized control trial of premature infants born(n = 66), comparing discontinuation of NCPAP from 6 cmH

RESULTS: Duration of NCPAP or mechanical ventilation was longer in the slow wean arm compared to the fast wean arm (17 vs 12 days, p = 0.03). There were no differences observed in secondary outcomes.

CONCLUSION: In weaning NCPAP, abrupt discontinuation may be associated with a shorter duration of positive pressure respiratory support compared to a gradual weaning strategy.

Keywords

Continuous Positive Airway Pressure, Feasibility Studies, Female, Gestational Age, Humans, Infant, Infant, Newborn, Infant, Premature, Pregnancy, Respiratory Distress Syndrome, Newborn, Ventilator Weaning, Risk factors, Outcomes research

Comments

PMID: 34511596

DOI

10.1038/s41372-021-01200-9

PMID

34511596

PMCID

PMC8435158

PubMedCentral® Posted Date

September 2021

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes