Recurrent Nontraumatic Subgaleal Hematomas in a Pediatric Patient With Sickle Cell Disease

Authors

Irtiza N Sheikh
Olayinka Okeleji
Rabya Afzal
Eliana Bonfante
Monica Kodakandla
Neethu M Menon

Publication Date

4-1-2024

Journal

Journal of Pediatric Hematology / Oncology

Abstract

Spontaneous subgaleal hematoma in pediatric patients with sickle cell disease (SCD) is a rare occurrence that can present with symptoms mimicking ischemic stroke, a known complication of SCD. However, unlike ischemic stroke, subgaleal hematoma is nonlethal and can be managed conservatively without major sequelae. Here, we present the case of an adolescent with SCD who presented with 2 episodes of subgaleal and epidural hematomas, 2 years apart. The latter episode occurred while on crizanlizumab, an anti-P-selectin antibody, approved for use in SCD in 2019 to reduce the number of acute pain crises. We demonstrate the diagnosis of subgaleal hematoma and outline steps to conservative management which were safe and did not lead to focal neurologic deficits.

Keywords

acute soft head syndrome, epidural hematoma, sickle cell disease, subgaleal hematoma, thrombocytosis, vaso-occlusive crises

Comments

PMID: 38408160