Publication Date
1-1-2022
Journal
Frontiers in Reproductive Health
Abstract
PURPOSE: The purpose of our study is to expand the knowledge regarding intrinsic reproductive dysfunction in females with TSC and to explore the impact of mTOR inhibitors (mTORi) on menstrual irregularity in the Tuberous Sclerosis Complex (TSC) community.
METHODS: An electronic survey composed of author-designed questions set out to evaluate reproductive history, presence of menstrual irregularities, mTORi use, as well as maternal reproductive history among females with TSC.
RESULTS: Of the 68 responses from females with TSC regarding age of menarche, the average age was 12.3 years. 56.5% (
CONCLUSIONS: Our data expands the knowledge regarding intrinsic menstrual dysregulation present in women with TSC, demonstrates a rate of menstrual irregularities among females taking mTORi, and identifies a tendency toward early menarche that may be a previously unrecognized feature of TSC.
Keywords
menstrual irregularity, tuberous sclerosis complex, mTOR dysregulation, mTOR inhibitors, reproductive health
Comments
PMID: 36303615