Faculty, Staff and Student Publications
Language
English
Publication Date
1-1-2023
Journal
Frontiers in Pediatrics
DOI
10.3389/fped.2023.1118874
PMID
37397151
PMCID
PMC10311071
PubMedCentral® Posted Date
June 2023
PubMedCentral® Full Text Version
Post-print
Abstract
Functional abdominal pain disorders (FAPDs) affect up to 25% of children in the United States. These disorders are more recently known as disorders of "brain-gut" interaction. The diagnosis is based on the ROME IV criteria, and requires the absence of an organic condition to explain the symptoms. Although these disorders are not completely understood, several factors have been involved in the pathophysiology including disordered gut motility, visceral hypersensitivity, allergies, anxiety/stress, gastrointestinal infection/inflammation, as well dysbiosis of the gut microbiome. The pharmacologic and non-pharmacologic treatments for FAPDs are directed to modifying these pathophysiologic mechanisms. This review aims to summarize the non-pharmacologic interventions used in the treatment of FAPDs including dietary modifications, manipulation of the gut microbiome (neutraceuticals, prebiotics, probiotics, synbiotics and fecal microbiota transplant) and psychological interventions that addresses the "brain" component of the brain-gut axis (cognitive behavioral therapy, hypnotherapy, breathing and relaxation techniques). In a survey conducted at a large academic pediatric gastroenterology center, 96% of patients with functional pain disorders reported using at least 1 complementary and alternative medicine treatment to ameliorate symptoms. The paucity of data supporting most of the therapies discussed in this review underscores the need for large randomized controlled trials to assess their efficacy and superiority compared to other treatments.
Keywords
functional gastrointestinal disorders, functional abdominal pain disorders, irritable bowel syndrome (IBS), non-pharmacologic, treatment
Published Open-Access
yes
Recommended Citation
Partha Sarathi Chakraborty, Rhea Daniel, and Fernando A Navarro, "Non-Pharmacologic Approaches To Treatment of Pediatric Functional Abdominal Pain Disorders" (2023). Faculty, Staff and Student Publications. 2275.
https://digitalcommons.library.tmc.edu/uthmed_docs/2275