Medical Management of Infants With Supraventricular Tachycardia: Results From A Registry and Review of The Literature

Authors

Nathan Wei
Avani Lamba
Sonia Franciosi
Ian H Law
Luis A Ochoa
Christopher L Johnsrude
Sit Yee Kwok
Teng Hong Tan
Santokh S Dhillon
Anne Fournier
Stephen P Seslar
Elizabeth A Stephenson
Andrew D Blaufox
Michel Cabrera Ortega
Jeffrey N Bone
Ash Sandhu
Carolina A Escudero
Shubhayan Sanatani

Language

English

Publication Date

2-1-2022

Journal

CJC Pediatric and Congenital Heart Disease

DOI

10.1016/j.cjcpc.2021.09.001

PMID

37969556

PMCID

PMC10642123

PubMedCentral® Posted Date

February 2022

PubMedCentral® Full Text Version

Post-print

Abstract

BACKGROUND: Several medication choices are available for acute and prophylactic treatment of refractory supraventricular tachycardia (SVT) in infants. There are almost no controlled trials, and medication choices are not necessarily evidence based. Our objective was to report the effectiveness of management strategies for infant SVT.

METHODS: A registry of infants admitted to hospital with re-entrant SVT and no haemodynamically significant heart disease were prospectively followed at 11 international tertiary care centres. In addition, a systematic review of studies on infant re-entrant SVT in MEDLINE and EMBASE was conducted. Data on demographics, symptoms, acute and maintenance treatments, and outcomes were collected.

RESULTS: A total of 2534 infants were included: n = 108 from the registry (median age, 9 days [0-324 days], 70.8% male) and n = 2426 from the literature review (median age, 14 days; 62.3% male). Propranolol was the most prevalent acute (61.4%) and maintenance treatment (53.8%) in the Registry, whereas digoxin was used sparingly (4.0% and 3.8%, respectively). Propranolol and digoxin were used frequently in the literature acutely (31% and 33.2%) and for maintenance (17.8% and 10.1%) (

CONCLUSION: This was the largest cohort of infants with SVT analysed to date. Digoxin monotherapy use was rare amongst contemporary paediatric cardiologists. There was limited evidence to support one medication over another. Overall, recurrence and mortality rates on antiarrhythmic treatment were low.

Published Open-Access

yes

Recommended Citation

Wei, Nathan; Lamba, Avani; Franciosi, Sonia; et al., "Medical Management of Infants With Supraventricular Tachycardia: Results From A Registry and Review of The Literature" (2022). Faculty, Staff and Student Publications. 2291.
https://digitalcommons.library.tmc.edu/uthmed_docs/2291