Nocturnal Dipping and Kidney Function Decline: Findings From the CKD in Children Study.

Authors

Christine Y Bakhoum
Manali Phadke
Yanhong Deng
Joshua A Samuels
Pranav S Garimella
Susan L Furth
F Perry Wilson
Joachim H Ix

Publication Date

11-1-2022

Journal

Kidney International Reports

Abstract

INTRODUCTION: Normally, blood pressure (BP) declines by at least 10% from daytime to nighttime. In adults, blunted nocturnal dipping has been associated with more rapid decline in kidney function. Nondipping is prevalent in children with chronic kidney disease (CKD). We sought to determine whether nondipping is associated with proteinuria and progression to kidney failure in children with CKD.

METHODS: In the prospective CKD in children (CKiD) cohort, Cox proportional hazards models were used to evaluate the relationship between baseline nondipping and progression to kidney failure. Linear mixed effects models were used to evaluate the relationship between nondipping and changes in iohexol glomerular filtration rate (GFR) and urine protein-to-creatinine ratio (log-UPCR, mg/mg) over time.

RESULTS: Among 620 participants, mean age was 11 (± 4) years, mean iohexol GFR was 52 (± 22) ml/min per 1.73 m

CONCLUSION: Nondipping is not associated with end-stage kidney disease, GFR decline, or change in proteinuria within the CKiD cohort.

Keywords

blood pressure, children, chronic kidney disease, dipping, hypertension, pediatrics

Comments

Supplementary Materials

PMID: 36531891