Faculty, Staff and Student Publications
Publication Date
10-1-2022
Journal
Bioactive Materials
Abstract
Multifunctional scaffolds with host defense peptides designed for regenerative endodontics are desirable nanobiotechnological tools for dentistry. Here, different scaffolds were tested for use during the pulp revascularization process, including poly(vinyl alcohol)-PVA hydrogels or resins, collagen hydrogels and poly(vinyl alcohol) PVA/Chitosan (PVA/CS) nanofibers. Based on time to degradation (21 days), nanofibers were chosen to be incorporated with ciprofloxacin and IDR-1002 (each at 50 mg/g). Nanofibers containing ciprofloxacin and IDR-1002 had anti-biofilm activity against
Keywords
Regenerative endodontics, Scaffolds, Nanofibers, Host defense peptides, Ciprofloxacin, IDR-1002
DOI
10.1016/j.bioactmat.2022.01.027
PMID
35386316
PMCID
PMC8965695
PubMedCentral® Posted Date
February 2022
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes