Publication Date
1-1-2023
Journal
Frontiers in Neuroscience
Abstract
Abnormal alpha-synuclein (α-SYN) protein deposition has long been recognized as one of the pathological hallmarks of Parkinson's disease's (PD). This study considers the potential utility of PD retinal biomarkers by investigating retinal changes in a well characterized PD model of α-SYN overexpression and how these correspond to the presence of retinal α-SYN. Transgenic A53T homozygous (HOM) mice overexpressing human α-SYN and wildtype (WT) control littermates were assessed at 4, 6, and 14 months of age (male and female,
Keywords
A53T, alpha-synuclein, Parkinson’s disease, retina, electroretinography, optical coherence tomography
Included in
Eye Diseases Commons, Neurology Commons, Neurosciences Commons, Ophthalmology Commons, Optometry Commons
Comments
Supplementary Materials
PMID: 37214398