Cortical Connectomic Mediations on Gamma Band Synchronization in Schizophrenia

Authors

Xiaoming Du
Stephanie Hare
Ann Summerfelt
Bhim M Adhikari
Laura Garcia
Wyatt Marshall
Peng Zan
Mark Kvarta
Eric Goldwaser
Heather Bruce
Si Gao
Hemalatha Sampath
Peter Kochunov
Jonathan Z Simon
L Elliot Hong

Publication Date

1-19-2023

Journal

Translational Psychiatry

Abstract

Aberrant gamma frequency neural oscillations in schizophrenia have been well demonstrated using auditory steady-state responses (ASSR). However, the neural circuits underlying 40 Hz ASSR deficits in schizophrenia remain poorly understood. Sixty-six patients with schizophrenia spectrum disorders and 85 age- and gender-matched healthy controls completed one electroencephalography session measuring 40 Hz ASSR and one imaging session for resting-state functional connectivity (rsFC) assessments. The associations between the normalized power of 40 Hz ASSR and rsFC were assessed via linear regression and mediation models. We found that rsFC among auditory, precentral, postcentral, and prefrontal cortices were positively associated with 40 Hz ASSR in patients and controls separately and in the combined sample. The mediation analysis further confirmed that the deficit of gamma band ASSR in schizophrenia was nearly fully mediated by three of the rsFC circuits between right superior temporal gyrus-left medial prefrontal cortex (MPFC), left MPFC-left postcentral gyrus (PoG), and left precentral gyrus-right PoG. Gamma-band ASSR deficits in schizophrenia may be associated with deficient circuitry level connectivity to support gamma frequency synchronization. Correcting gamma band deficits in schizophrenia may require corrective interventions to normalize these aberrant networks.

Keywords

Humans, Evoked Potentials, Auditory, Acoustic Stimulation, Connectome, Auditory Cortex, Electroencephalography, Schizophrenia, Diagnostic markers

Comments

PMID: 36653335