Effects of Independent Versus Dependent Stressful Life Events On Major Symptom Domains of Schizophrenia

Authors

Yizhou Ma
Joshua Chiappelli
Mark D Kvarta
Heather Bruce
Andrew van der Vaart
Eric L Goldwaser
Xiaoming Du
Hemalatha Sampath
Samantha Lightner
Jane Endres
Akram Yusuf
Alexa Yuen
Samantha Narvaez
Danny Campos-Saravia
Peter Kochunov
L Elliot Hong

Publication Date

12-8-2023

Journal

Schizophrenia

Abstract

We evaluated two models to link stressful life events (SLEs) with the psychopathology of schizophrenia spectrum disorders (SSD). We separated SLEs into independent (iSLEs, unlikely influenced by one's behavior) and dependent (dSLEs, likely influenced by one's behavior). Stress-diathesis and stress generation models were evaluated for the relationship between total, i- and d- SLEs and the severity of positive, negative, and depressive symptoms in participants with SSD. Participants with SSD (n = 286; 196 males; age = 37.5 ± 13.5 years) and community controls (n = 121; 83 males; 35.4 ± 13.9 years) completed self-report of lifetime negative total, i- and d- SLEs. Participants with SSD reported a significantly higher number of total SLEs compared to controls (B = 1.11, p = 6.4 × 10

Keywords

Schizophrenia, Human behaviour

DOI

10.1038/s41537-023-00415-3

PMID

38065979

PMCID

PMC10709301

PubMedCentral® Posted Date

December 2023

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes