Publication Date
10-6-2022
Journal
Molecular Psychiatry
Abstract
Major depressive disorder (MDD) is a psychiatric disease of still poorly understood molecular etiology. Extensive studies at different molecular levels point to a high complexity of numerous interrelated pathways as the underpinnings of depression. Major systems under consideration include monoamines, stress, neurotrophins and neurogenesis, excitatory and inhibitory neurotransmission, mitochondrial dysfunction, (epi)genetics, inflammation, the opioid system, myelination, and the gut-brain axis, among others. This review aims at illustrating how these multiple signaling pathways and systems may interact to provide a more comprehensive view of MDD's neurobiology. In particular, considering the pattern of synaptic activity as the closest physical representation of mood, emotion, and conscience we can conceptualize, each pathway or molecular system will be scrutinized for links to synaptic neurotransmission. Models of the neurobiology of MDD will be discussed as well as future actions to improve the understanding of the disease and treatment options.
Keywords
Humans, Depressive Disorder, Major, Synapses, Synaptic Transmission, Inflammation, Signal Transduction
Included in
Medical Specialties Commons, Mental and Social Health Commons, Neurosciences Commons, Psychiatry and Psychology Commons, Psychology Commons
Comments
PMID: 36203007