Faculty, Staff and Student Publications

Language

English

Publication Date

11-1-2009

Journal

CNS & Neurological Disorders - Drug Targets

DOI

10.2174/187152709789541998

PMID

19702573

PMCID

PMC2804467

PubMedCentral® Posted Date

1-11-2010

PubMedCentral® Full Text Version

Author MSS

Abstract

Protein Misfolding Disorders (PMDs) are a group of diseases characterized by the accumulation of abnormally folded proteins. Despite the wide range of proteins and tissues involved, PMDs share similar molecular and pathogenic mechanisms. Several epidemiological, clinical and experimental reports have described the co-existence of PMDs, suggesting a possible cross-talk between them. A better knowledge of the molecular basis of PMDs could have important implications for understanding the mechanism by which these diseases appear and progress and ultimately to develop novel strategies for treatment. Due to their similar molecular mechanisms, common therapeutic strategies could be applied for the diseases in this group.

Keywords

Prion Diseases, Protein Conformation, Protein Folding, Proteostasis Deficiencies

Published Open-Access

yes

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