The Role of Extracellular Heat Shock Proteins in Cardiovascular Diseases

Authors

Soumya Patnaik
Sriram Nathan
Biswajit Kar
Igor D Gregoric
Yi-Ping Li

Language

English

Publication Date

5-27-2023

Journal

Biomedicines

DOI

10.3390/biomedicines11061557

PMID

37371652

PMCID

PMC10295776

PubMedCentral® Posted Date

5-27-2023

PubMedCentral® Full Text Version

Post-print

Abstract

In the early 1960s, heat shock proteins (HSPs) were first identified as vital intracellular proteinaceous components that help in stress physiology and reprogram the cellular responses to enable the organism's survival. By the early 1990s, HSPs were detected in extracellular spaces and found to activate gamma-delta T-lymphocytes. Subsequent investigations identified their association with varied disease conditions, including autoimmune disorders, diabetes, cancer, hepatic, pancreatic, and renal disorders, and cachexia. In cardiology, extracellular HSPs play a definite, but still unclear, role in atherosclerosis, acute coronary syndromes, and heart failure. The possibility of HSP-targeted novel molecular therapeutics has generated much interest and hope in recent years. In this review, we discuss the role of Extracellular Heat Shock Proteins (Ec-HSPs) in various disease states, with a particular focus on cardiovascular diseases.

Keywords

heat shock proteins, apoptosis, atherosclerosis, heart failure, ischemia-reperfusion injury, immune cell activation, stress

Published Open-Access

yes

Recommended Citation

Patnaik, Soumya; Nathan, Sriram; Kar, Biswajit; et al., "The Role of Extracellular Heat Shock Proteins in Cardiovascular Diseases" (2023). Faculty, Staff and Student Publications. 2572.
https://digitalcommons.library.tmc.edu/uthmed_docs/2572