Publication Date
12-1-2022
Journal
Biomarkers in Neuropsychiatry
Abstract
Complement system is one of the most important defense mechanisms of the innate immune system. In addition to their roles in immune regulation, complement proteins are also involved in neurodevelopment and adult brain plasticity. Complement dysregulation has been shown in neurodevelopmental disorders including schizophrenia and autism spectrum disorder as well as in mood disorders. A number of clinical as well as genetic studies suggest the role of complement proteins in the cortical thinning and excessive synaptic pruning frequently associated with schizophrenia. The changes in complement proteins are also associated with the pathophysiology of autism spectrum disorder, major depressive disorder and bipolar disorder, but warrant further research. In addition, rodent models suggest a strong case for complement system in anxiety-like behavior. In this article, we review the recent findings on the role of complement system in neuropsychiatric disorders. The possible uses for future complement targeted therapies are also discussed.
Keywords
Complement, Immune system, Depression, Schizophrenia, ASD, Synaptic plasticity, Anxiety
Included in
Biological Phenomena, Cell Phenomena, and Immunity Commons, Medical Specialties Commons, Mental and Social Health Commons, Psychiatry and Psychology Commons, Psychology Commons
Comments
PMID: 37123465