Publication Date
11-1-2021
Journal
Mitochondrion
Abstract
Mitochondria, the 'powerhouse' of eukaryotic cells, play a key role in cellular homeostasis. However, defective mitochondria increase mitochondrial ROS (mtROS) production and cell-free mitochondrial DNA (mtDNA) release, leading to increased inflammation. Mitophagy is a vital pathway, which selectively removes defective mitochondria through the process of autophagy. Thus, an impairment in the mitophagy pathway might trigger the gradual accumulation of defective mitochondria. Accumulating evidence suggest that inflammation and mitochondrial dysfunction are linked to the pathogenesis of depression. In this article, we have reviewed the role of impaired mitophagy as a contributing factor in depression pathophysiology. Further, we have discussed the potential therapeutic interventions aimed at modulating mitophagy in depression.
Keywords
Depression, Humans, Mitochondria, Mitophagy
Included in
Medical Sciences Commons, Mental and Social Health Commons, Pathological Conditions, Signs and Symptoms Commons, Pathology Commons, Psychiatry and Psychology Commons, Psychology Commons
Comments
PMID: 34478906