Posttraumatic Stress Symptom Clusters Differentially Predict Late Positive Potential to Cocaine Imagery Cues in Trauma-Exposed Adults With Cocaine Use Disorder

Authors

Heather E Webber
Danielle A Kessler
Emma C Lathan
Margaret C Wardle
Charles E Green
Joy M Schmitz
Scott D Lane
Anka A Vujanovic

Publication Date

10-1-2021

Journal

Drug Alcohol Dependence

Abstract

BACKGROUND: While studies have investigated the effects of posttraumatic stress disorder (PTSD) symptoms on substance use, information on these associations in the context of drug cue reactivity is lacking, which can provide meaningful information about risk for relapse. The current study assessed the associations between PTSD symptom clusters and reactivity to cues in trauma-exposed adults with cocaine use disorder.

METHODS: We recorded electroencephalogram on 52 trauma-exposed participants (M

RESULTS: Linear mixed modeling indicated that higher NACM symptomatology was associated with higher LPPs to cocaine cues and higher arousal/reactivity was associated with lower LPPs to cocaine cues.

CONCLUSIONS: These results highlight the potential clinical utility of the LPP in assessing drug cue reactivity in trauma-exposed adults with substance use disorder.

Keywords

trauma, PTSD, late positive potential, cocaine use disorder, mood, cue reactivity

Comments

PMID: 34340161