Editorial: Metabolic Regulation Under Oxidative Stress in Cancer

Authors

Elavarasan Subramani
Abishai Dominic
Pratip K Bhattacharya
Daniel E Frigo
Ilya Bederman
Ali Vaziri-Gohar

Publication Date

1-1-2023

Journal

Frontiers in Oncology

Abstract

Oxidative stress has emerged as a key component of cancer metabolism that impacts multiple facets of tumor biology (1). Recent studies have shed light on the complex interplay of cellular redox and its impact on molecular mechanisms that govern metabolic reprogramming under oxidative stress (2, 3). It is well established that altered glucose metabolism exhibited by tumor cells leads to an enormous oxidative burden through various metabolic routes (4, 5). What is less known but remains a great interest to the field is whether elevated oxidative stress has a causal role in the development of aggressive and resistant tumor phenotypes (6). To that end, this Research Topic explores various metabolic routes that protect tumor cells against oxidative stress in diverse cancer models. It is anticipated that the development of advanced therapeutic approaches requires an in-depth understanding of the oxidative stress-mediated metabolic processes in cancer, including its effects on aspects of the tumor milieu such as immune cells-related functions.

Comments

PMID: 37771445